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Why, Calcium?

Calcium plays a key role in conducting electricity in our bodies. When calcium is out of balance it adversely affects the nervous system. Calcium also plays a role in muscle contractions, including the contractions of the heart muscle. It is a building block of healthy bones and teeth and is involved in the blood-clotting process.

Hypoparathyroidism (HPTH)

HPTH is a disorder causing lower-than-normal levels of calcium in the blood due to insufficient levels of parathyroid hormone (PTH). HPTH is an uncommon endocrine deficiency disease characterized by low serum calcium levels, elevated serum phosphorus levels, and absent or inappropriately low levels of parathyroid hormone.

Occurrence rate: ~75K patients in the U.S., 41K with moderate or severe disease, about 0.0002% of the US population

Hypoparathyroidism is the last classical endocrine deficiency disease for which treatment with the missing hormone is not standard therapy

A major therapeutic challenge is consistent effective management of the hypocalcemia while avoiding hypercalcemia and other complications.

Hypocalcemia: abnormally low levels of calcium and high levels of phosphorous in the blood.

Contributing factors include: Weather (extreme hot and cold); infections; changes in medications for other conditions; strenuous exercise; anxiety or stressful situations; changes in diet that reduce calcium or vitamin D intake; abnormalities in your magnesium and/or phosphorus levels; menstruation; diarrhea, constipation or other intestinal conditions that keep a person from absorbing their calcium effectively. In severe cases, seizures, cardiac arrhythmia and laryngospasms (seizure of the voice box) can occur.

 
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At this stage people with HPTH rely on self-regulated management. Imagine having diabetes in 2018 without the aid of a glucose monitor to guide treatment at home. This is Hypopara.

The lack of accessible monitoring at home can lead to hypercalcemia — too much calcium in the blood resulting in nausea, vomiting, dizziness, and in severe cases, coma.